ISRCTN11976737已完成未知
The effect of on demand versus continuous use of proton pump inhibitors on reflux symptoms, quality of life and self-rated health in patients with gastro-oesophageal reflux disease
Karolinska Institute0 个研究点目标入组 488 人开始时间: 2015年3月5日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 488
研究概览
简要总结
2019 results presented at the American Gastroenterological association (AGA) conference in https://www.gastrojournal.org/article/S0016-5085(19)37030-1/fulltext (added 06/10/2020)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Age 18-65 years
- •2. Predominant GORD cases with heartburn and/or acid regurgitation that need PPI treatment
- •3. PPI responsive
- •4. Ability to complete questionnaires
排除标准
- •1. Known Barrett’s oesophagus
- •2. Known severe oesophagitis (LA C or above)
- •3. Continuous use of NSAID/aspirin
- •4. Prophylactic PPI use to reduce the risk of ulcers in persons being treated with NSAIDs
- •5. PPI treatment to heal an ulcer induced by NSAID treatment in the last 6 months
- •6. PPI treatment for H. pylori eradication in the last 6 months
- •7. Severe disorders other than GORD with a negative impact on quality of life
- •8. Signs of upper gastrointestinal bleeding
- •9. Alarm symptoms: unintentional weight loss/vomiting/difficulties swallowing
- •10. Pregnancy
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