Effects of Acetaminophen Preemptive Analgesia on Anesthesia Recovery Time and Postoperative Cognitive Function in Patients Undergoing Gastrointestinal Tumor Surgery
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Postoperative delirium
研究概览
简要总结
Patients undergoing gastrointestinal tumor surgery are prone to delayed recovery and postoperative cognitive dysfunction due to greater trauma and longer operation time. Pre-analgesia can reverse the effects of nociceptive stimulation on recovery from general anesthesia and postoperative cognitive function. Intravenous injection of non-steroidal drugs can effectively reduce postoperative pain and the use of opioids. Therefore, This study selected acetaminophen mannitol injection for preemptive analgesia to observe the effects on anesthesia recovery time and postoperative cognitive function of patients undergoing gastrointestinal tumor surgery, providing new ideas for reducing cognitive dysfunction in patients undergoing gastrointestinal tumor surgery
详细描述
By administering acetaminophen to patients with gastrointestinal tumors before surgery, recording the time to recovery from anesthesia, and assessing cognitive function status by CAM on the first, third, and seventh day after surgery
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 16 Years 至 88 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing gastrointestinal tumor surgery
- •American Society of Anesthesiologists（ASA）≤Ⅲ
排除标准
- •History of severe adverse reactions to oral acetaminophen
- •Dysfunction of heart, liver, kidney and other important organs
- •History of chronic pain
- •Oral non-steroidal or opioid drugs
- •Patients who do not accept clinical trials
研究组 & 干预措施
By applying acetaminophen mannitol to patients with gastrointestinal tumors before surgery
Acetaminophen mannitol injection 50ml(500mg) intravenously pumped 30 minutes before surgery
干预措施: acetaminophen mannitol (Drug)
By applying normal saline to patients with gastrointestinal tumors before surgery
Normal saline injection 50ml intravenously pumped 30 minutes before surgery
干预措施: Normal saline (Drug)
结局指标
主要结局
Postoperative delirium
时间窗: 1/3/7 days after the surgery
The confusion assessment method (CAM) was used to assess postoperative cognitive dysfunction
次要结局
- Recovery time(immediately after the surgery)