Targeting Myosteatosis Though Physical Exercise to Treat Metabolic Dysfunction-associated Steatotic Liver Disease
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 60
- 试验地点
- 3
- 主要终点
- the impact of physical activity on muscle and liver phenotypes
研究概览
简要总结
Muscle changes including myosteatosis are reported as highly prevalent in metabolic dysfunction-associated steatotic liver disease (MASLD). Recent studies highlighted a link between muscle fat content and liver disease severity. Conversely, MASLD histological remission though diet or metabolic surgeries is also linked to a decrease in muscle fat content. Therefore, skeletal muscle appears as a potential target to treat MASLD.
详细描述
In this monocenter interventional study, we will assess the impact of physical activity on muscle fat content and liver disease severity in MASLD as well as the mechanisms mediating the potential beneficial effects of exercise.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •confirmed MASLD at abdominal imaging
- •confirmed excessive muscle lipid content at imaging
- •stable weight
排除标准
- •severe comorbidities including active malignancies, neuromuscular degenerative diseases
- •contraindications to physical activity
- •excessive alcohol consumption
研究组 & 干预措施
moderate-intensity low interval training group
In this group, patients will perform moderate-intensity low interval training.
干预措施: Moderate intensity exercise training (Other)
high-intensity interval training
In this group, patients willp erform high-intensity interval training.
干预措施: High-intensity interval training (Other)
control group
in this control group, patients will perform non-cardiovascular non-intensity training (stretching, meditation).
干预措施: Low intensity exercise training (Other)
结局指标
主要结局
the impact of physical activity on muscle and liver phenotypes
时间窗: every four weeks from baseline till study completion
the investigators will assess at baseline and every four weeks till study completion the impact of intervention on liver phenotype assessed by transient elastography and muscle phenotype assessed by MRI
次要结局
未报告次要终点