NCT01483313撤回不适用
Intelligence Performance in Adolescence After Early Exposure to Anesthesia and Minor Surgery
适应症
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Wechsler Intelligence Scale for Children
研究概览
简要总结
Animal studies showed that many general anesthetics might result in neuron apoptosis and neurocognitive impairment in the developing brain. However results from human studies are conflicted. In present study, the investigators examined the association between early exposure to anesthesia and surgery for minor surgery and intelligence changes in adolescence using the Wechsler Intelligence Scale for Children.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 6 Years 至 16 Years（Child）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Born from 1995
- •Parents or guardian agree to attend this study
- •Undergone minor surgery (Repair of hypospadias, phimosiectomy, cryptorchidectomy or cryptorchidopexy and repair of inguinal hernia)
- •Children who scarify the No.1 to No.3 but no experience of any surgery.
- •Those who undergone minor surgery in Renji Hospital 4-6years ago.
排除标准
- •Any congenital central nervous system diseases
- •Any congenital heart diseases
- •Any congenital dysgnosia
- •Birth weight less than 2kg
- •Ever been hypoxic encephalopathy when birth
结局指标
主要结局
Wechsler Intelligence Scale for Children
时间窗: Average 5 years after surgery
Wechsler Intelligence Scale for Children will be done after surgery, the expected average of 5 years after surgery.
次要结局
- Achenbach Child Behavior Checklist(Average 5 years after surgery)
研究者
diansan su
Principal Investigator
RenJi Hospital
研究点 (1)
Loading locations...
相似试验
Unknown
不适用
Anaesthesia and ApoptosisApoptosisNCT04431505Assiut University20
进行中（未招募）
3 期
A Study to Compare the Long-term Outcomes After Two Different AnaestheticsAnesthesiaNeurotoxicityChild DevelopmentNCT03089905Murdoch Childrens Research Institute450
已完成
不适用
Autism & Anesthetic Exposure StudyAutism Spectrum DisorderNCT03514498The Hospital for Sick Children51
撤回
3 期
Neuroinflammatory and Neurocognitive Effects of Spinal vs. Inhalational Anesthesia for Elective Surgery in InfantsInguinal HerniaNCT02521831Emmett Whitaker, M.D.
已完成
4 期
The effects of anaesthesia on neurodevelopmental outcome and apnoe in infants: the GAS study.anesthesiologieneurodevelopmental outcome10010335NL-OMON38102niversitair Medisch Centrum Utrecht40