Glycemic Response of Co-ingesting Carbohydrate and Amino Acids
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 23
- 主要终点
- Insulinemic response
研究概览
简要总结
The study will investigate if consumption of amino acid mixtures results a change in glycemic response of carbohydrate (white rice) and insulinemic response at different doses and timing (before consumption of carbohydrate).
详细描述
Healthy male subjects will be served with amino acid mixtures in combinations of two doses and three time points along with white rice as control. The combinations were either low or high levels of amino acid mixtures. This was consumed together or 15 min, 30 min before consumption of white rice. Postprandial blood glucose and plasma insulin concentrations were measured at fasting and every 15 min after consumption of treatment meal until 60 min after the consumption of white rice. Subsequent blood sample were taken at 30 min interval until 210min. The glucose and insulin in the blood will be analysed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Chinese ethnicity
- •Age between 21-50 years
- •Body mass index (BMI) between 18-24.9 kg/m2
- •Waist circumference ≤ 90 cm for men
- •Normal blood pressure (<120/80 mmHg)
- •Fasting blood glucose < 6 mmol/L
排除标准
- •dislike the consumption of Essence of Chicken
- •participating in competitive sports
- •allergic to amino acids and rice
- •metabolic diseases (such as diabetes, hypertension and the metabolic syndromes)
- •Glucose-6-Phosphate-Dehydrogenase (G6PD) Deficiency
- •on prescription medication
结局指标
主要结局
Insulinemic response
时间窗: 210 minutes post consumption of carbohydrate
Plasma insulin will be assessed via finger prick during fasting and every 15 minutes for the first 60 min after the consumption white rice and subsequently every 30 min interval until 210 min
Glycemic response
时间窗: 210 minutes post consumption of carbohydrate
Blood glucose will be assessed via finger prick during fasting and every 15 minutes for the first 60 min after the consumption white rice and subsequently every 30 min interval until 210 min
次要结局
未报告次要终点
研究者
JeyaKumar Henry
Principal Investigator
Clinical Nutrition Research Centre, Singapore