Swiss Atrial Fibrillation Cohort Study - SWISS AF
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 2,415
- 试验地点
- 1
- 主要终点
- Stroke or systemic embolism
研究概览
简要总结
Swiss-AF is a prospective observational, multicentric cohort study in Switzerland. Overall, 2600 patients with documented atrial fibrillation aged >65 years will be included and followed on a yearly basis.
Yearly clinical examinations include a detailed questionnaire on personal characteristics, a resting electrocardiogram, neurocognitive function tests and questionnaires on disability and quality of life. Blood sampling and brain magnetic resonance imaging are scheduled at baseline and after 2 years of follow-up.
The main study aims of this long term prospective study are to increase our knowledge on structural brain damage and its changes over time in patients with atrial fibrillation, to gain additional insights on the incidence and underlying mechanisms of cognitive decline in patients with atrial fibrillation and to evaluate the interrelationships of structural and functional brain damage in this population.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 45 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •atrial fibrillation documented within the last 24 months
- •age >=45 years
排除标准
- •acute illness
- •inability to provide informed consent
- •Only short episodes of reversible forms of atrial fibrillation
结局指标
主要结局
Stroke or systemic embolism
时间窗: 2018 (after an average of 2.5 years of follow-up)
次要结局
- Hospitalization for heart failure(2018 (after an average of 2.5 years of follow-up))