Using Neuroimage and Computational Modeling to Customize High-definition Transcranial Direct Current Stimulation Protocols for Facilitating Hand Function Recovery After Stroke
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Action Research Arm Test (ARAT)
研究概览
简要总结
Transcranial direct current stimulation (tDCS) had recently been shown having feasibility in modulating cortical excitability transiently during motor training in a noninvasive way. The findings support that tDCS and motor practice can positively promote post-stroke motor learning to improve upper-limb motor recovery after stroke. A randomized controlled trial will be conducted with three groups: HD-tDCS, conventional tDCS and sham HD-tDCS. A 10-session training will be provided to evaluate the effectiveness of transient modulation of cortical excitability through tDCS with clinical assessment scores.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Hemiparesis subsequent to first-ever unilateral stroke for more than 6 months;
- •MCP and PIP finger joints can be extended to 180° passively;
- •Sufficient cognition to follow the experimental instructions
排除标准
- •Severe hand spasticity or hand deformity;
- •History of alcohol or drug abuse or epilepsy;
- •Bilateral brain infarcts;
- •Severe cognitive deficits;
- •Comprehensive aphasia;
- •Contraindications to tDCS
结局指标
主要结局
Action Research Arm Test (ARAT)
时间窗: 3-month after the 10th session training
The ARAT has total 19 items, divided into 4 categories (grasp, grip, pinch, and gross arm movement). It ranges from 3 to 0 (best to worse).
次要结局
- Fugl-Meyer Assessment (Upper Extremity)(3-month after the 10th session training)
- Magnetic Resonance Imaging(Baseline)
- Wolf Motor Function Test (WMFT)(3-month after the 10th session training)
研究者
Raymond KY Tong
Chairman and Professor
Chinese University of Hong Kong