Einfluss Des Energy Flux Auf Die Kurzfristige Regulation Der Energie- Und Makronährstoffbilanz
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 2
- 主要终点
- energy balance
研究概览
简要总结
Aim of the study is to investigate the impact of energy flux (achieved by changes in physical activity) under the conditions of energy balance, caloric restriction and overfeeding in healthy subjects.
详细描述
A low energy flux is achieved by low energy expenditure, equivalent to low physical activity and with a corresponding low energy intake. A high energy flux is achieved by high energy expenditure, equivalent to high physical activity and with a corresponding high energy intake, respectively.
The protocol of this randomized, intra-individual nutrition intervention includes 12 one-day interventions with 3 different levels of energy flux and 4 different diet conditions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •20-40 years of age
- •BMI between 18.5 and 31 kg/m2
排除标准
- •food allergies
- •alternative nutrition habits like vegetarian / vegan
- •chronic diseases
- •regular medication intake
- •claustrophobia
- •weight loss > 5 kg in the last 3 years
研究组 & 干预措施
low energy flux at overfeeding
physical activity: inactive energy intake: overfeeding +25%
干预措施: physical activity (Behavioral)
low energy flux at overfeeding
physical activity: inactive energy intake: overfeeding +25%
干预措施: energy intake (Behavioral)
low energy flux at ad libitum energy intake
physical activity: inactive energy intake: ad libitum
干预措施: physical activity (Behavioral)
low energy flux at ad libitum energy intake
physical activity: inactive energy intake: ad libitum
干预措施: energy intake (Behavioral)
medium energy flux at ad libitum energy intake
physical activity: medium (3 x 55 min treadmill running at 4 km/h) energy intake: ad libitum
干预措施: physical activity (Behavioral)
medium energy flux at ad libitum energy intake
physical activity: medium (3 x 55 min treadmill running at 4 km/h) energy intake: ad libitum
干预措施: energy intake (Behavioral)
high energy flux at ad libitum energy intake
physical activity: high (3 x 110 min treadmill running at 4 km/h) energy intake: ad libitum
干预措施: physical activity (Behavioral)
high energy flux at ad libitum energy intake
physical activity: high (3 x 110 min treadmill running at 4 km/h) energy intake: ad libitum
干预措施: energy intake (Behavioral)
Low energy flux at energy balance
physical activity: inactive energy intake: individual energy balance
干预措施: physical activity (Behavioral)
Low energy flux at energy balance
physical activity: inactive energy intake: individual energy balance
干预措施: energy intake (Behavioral)
medium energy flux at energy balance
physical activity: medium (3 x 55 min treadmill running at 4 km/h) energy intake: individual energy balance
干预措施: physical activity (Behavioral)
high energy flux at overfeeding
physical activity: high (3 x 110 min treadmill running at 4 km/h) energy intake: overfeeding +25%
干预措施: physical activity (Behavioral)
high energy flux at overfeeding
physical activity: high (3 x 110 min treadmill running at 4 km/h) energy intake: overfeeding +25%
干预措施: energy intake (Behavioral)
medium energy flux at energy balance
physical activity: medium (3 x 55 min treadmill running at 4 km/h) energy intake: individual energy balance
干预措施: energy intake (Behavioral)
high energy flux at energy balance
physical activity: high (3 x 110 min treadmill running at 4 km/h) energy intake: individual energy balance
干预措施: physical activity (Behavioral)
high energy flux at energy balance
physical activity: high (3 x 110 min treadmill running at 4 km/h) energy intake: individual energy balance
干预措施: energy intake (Behavioral)
low energy flux at caloric restriction
physical activity: inactive energy intake: caloric restriction -25%
干预措施: physical activity (Behavioral)
low energy flux at caloric restriction
physical activity: inactive energy intake: caloric restriction -25%
干预措施: energy intake (Behavioral)
medium energy flux at caloric restriction
physical activity: medium (3 x 55 min treadmill running at 4 km/h) energy intake: caloric restriction -25%
干预措施: physical activity (Behavioral)
medium energy flux at caloric restriction
physical activity: medium (3 x 55 min treadmill running at 4 km/h) energy intake: caloric restriction -25%
干预措施: energy intake (Behavioral)
high energy flux at caloric restriction
physical activity: high (3 x 110 min treadmill running at 4 km/h) energy intake: caloric restriction -25%
干预措施: physical activity (Behavioral)
high energy flux at caloric restriction
physical activity: high (3 x 110 min treadmill running at 4 km/h) energy intake: caloric restriction -25%
干预措施: energy intake (Behavioral)
medium energy flux at overfeeding
physical activity: medium (3 x 55 min treadmill running at 4 km/h) energy intake: overfeeding +25%
干预措施: physical activity (Behavioral)
medium energy flux at overfeeding
physical activity: medium (3 x 55 min treadmill running at 4 km/h) energy intake: overfeeding +25%
干预措施: energy intake (Behavioral)
结局指标
主要结局
energy balance
时间窗: 24 hours
difference between predefined energy balance and measured energy balance
次要结局
- ghrelin levels(every 2 hours during the day over 14 hours)
- arterial stiffness(15 hours)