NCT00835523已完成不适用
OHSS Prevention by GnRH-agonist Triggering of Final Oocyte Maturation and Cryoperservation of All Two-pronucleate Oocytes in Women Undergoing Stimulation for IVF With Gonadotrophins and GnRH-analogues: a Prospective, Observational, Multicentric, Clinical Cohort Study
University Hospital Schleswig-Holstein10 个研究点 分布在 1 个国家目标入组 51 人开始时间: 2008年5月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 51
- 试验地点
- 10
- 主要终点
- Cumulative ongoing pregnancy rate (10-12 GWs) per patient within 12 months
研究概览
简要总结
The aim of the study is to explore the concept of GnRH-agonist triggering in combination with elective cryopreservation of all 2PN oocytes at larger scale in a pragmatic clinical setting. The question asked is: "Does GnRH-agonist triggering and cryopreservation work", in terms of efficacy and safety, when applied to a larger cohort of patients, and by a number of different centres with different clinical routines.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 39 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Indication for IVF with ICSI
- •Age < 40 years
- •< 4 failed previous IVF attempts with embryo transfer
- •ovarian stimulation with GnRH-antagonist and gonadotrophins
- •>20 follicles >11 mm in mean diameter or E2 >4500 pg/ml on the day , on which it was planned to administer hCG
- •willing to participate and able to consent
- •patient has not previously received GnRH-agonist as a trigger of final oocyte maturation
排除标准
- 未提供
结局指标
主要结局
Cumulative ongoing pregnancy rate (10-12 GWs) per patient within 12 months
时间窗: 12 months after recruitment
次要结局
- ongoing pregnancy rate/frozen-thawed ET(12 months after recruitment)
- Ongoing pregnancy rate/first frozen-thawed ET(12 months after recruitment)
- time to pregnancy in weeks(12 months after recruitment)
- incidence of OHSS III°(12 months after recruitment)
- number of cumulus-oocyte-complexes(12 months after recruitment)
- fertilization rate (number COCs/number of 2 PN oocytes(12 months after recruitment)
- survival rate (number of vital embryos/number of frozen 2 PN oocytes(12 months after recruitment)
研究者
Georg Griesinger
Director of Department of Reproductive Medicine
University Hospital Schleswig-Holstein
研究点 (10)
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