Follicular Challenge Test to Predict Response to GnRH Agonist Triggering
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- The response to GnRH triggering
研究概览
简要总结
GnRH agonist triggering is used during ART in order to reduce the risk of OHSS. Some studies described that in up to 5% of the cycles triggered with GnRH agonist, a lack of respone or suboptimal response was displayed.
The investigators aim to asses the possibility to predict the respone to ovulation triggering by the response to decapeptyl in the follicular phase of the same cycle.
详细描述
The investigators will use Decapeptyl on day 2 of menstruation followed by antagonist protocol.
Hormonal proflie including E2, P, LH, FSH will be measured. LH surge and the rest of the hormonal profile will be compared to day after ovulation triggering.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 41 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •patients that undergo fertility preservation
- •patients planned to freeze embryos due to PGT or surrogacy --patients at high risk for OHSS
排除标准
- •Poor ovarian response
- •known hypothalamic- pituitary dysfunction
结局指标
主要结局
The response to GnRH triggering
时间窗: One treatment cycle (each cycle is 28 days) for each participant (up to 28 days).
LH levels 10-12 hours after decapeptyl trigger, number of mature oocytes
次要结局
未报告次要终点
研究者
Assaf Harofeh MC
senior physician
Assaf-Harofeh Medical Center