Sympathetic Reactivity to Water Restriction in Young and Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 35
- 试验地点
- 1
- 主要终点
- Blood Pressure Variability
研究概览
简要总结
The goal of this project is determine how acute mild dehydration impacts blood pressure control at rest and during static exercise. This protocol will test healthy young and older adults in a normally hydrated and dehydrated condition.
详细描述
The purpose of this project is determine how acute mild dehydration impacts blood pressure control at rest and during static exercise. Additionally, we will determine whether or not the sympathetic nervous system has a role in mediating blood pressure control at rest and during static exercise. This protocol will test healthy young and older adults in a normally hydrated and dehydrated condition. This will allow for a within participant comparison. Additionally, we will later determine if age alters blood pressure control at rest or during static exercise.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 20 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age: 20-35 years old
排除标准
- •high blood pressure (>140/90 mmHg)
- •history of cardiovascular disease
- •history of cancer
- •history of diabetes
- •history of kidney disease
- •obesity (BMI > 30 kg/m2)
- •smoking or tobacco use
- •current pregnancy
- •nursing mothers
- •communication barriers
- •Inclusion Criteria (Older):
- •age: 60-75 years old
- •ECG within normal limits
- •screening blood panel within normal limits
- •Exclusion Criteria (Older):
- •high blood pressure (>140/90 mmHg)
- •history of cardiovascular disease
- •history of cancer
- •history of diabetes
- •history of kidney disease
- •obesity (BMI > 30 kg/m2)
- •smoking or tobacco use
- •current pregnancy
- •nursing mothers
- •communication barriers
研究组 & 干预措施
Normal hydration then dehydration
Participants will consume water to maintain proper hydration for three days prior to testing (visit 1). Seven to 60 days later, participants will reduce water intake over three days and abstain from any water for the final 16 hours prior to testing (visit 2).
干预措施: Normal hydration (Other)
Normal hydration then dehydration
Participants will consume water to maintain proper hydration for three days prior to testing (visit 1). Seven to 60 days later, participants will reduce water intake over three days and abstain from any water for the final 16 hours prior to testing (visit 2).
干预措施: Dehydration (Other)
Dehydration than normal hydration
Participants will reduce water intake over three days and abstain from any water for the final 16 hours prior to testing (visit 1). Seven to 60 days later, participants will consume water to maintain proper hydration for three days prior to testing (visit 2).
干预措施: Normal hydration (Other)
Dehydration than normal hydration
Participants will reduce water intake over three days and abstain from any water for the final 16 hours prior to testing (visit 1). Seven to 60 days later, participants will consume water to maintain proper hydration for three days prior to testing (visit 2).
干预措施: Dehydration (Other)
结局指标
主要结局
Blood Pressure Variability
时间窗: During experimental visits 1 and 2
Blood pressure variability (BPV) was calculated using standard deviation and using the average real variability index of blood pressure values. The average real variability index calculates the average of absolute differences between consecutive BP measurements and is thought to provide further prognostic value compared with traditional measures of BPV.
Blood Pressure Reactivity - Handgrip Exercise
时间窗: During experimental visits 1 and 2
Change in systolic blood pressure during the second-minute handgrip exercise minus compared to pre-exercise baseline (i.e., at rest).
次要结局
未报告次要终点