NCT03860714Unknown不适用
Correlation Between Urine UACR and Postoperative Neurocognitive Disorder in Elderly Patients With Non-cardiac Surgery
Han Yuan1 个研究点 分布在 1 个国家目标入组 400 人开始时间: 2019年1月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- Confusion Assessment Method（CAM)
研究概览
简要总结
This study intends to evaluate the relationship between urinary albumin/creatinine ratio and postoperative neurocognitive impairment in elderly non-cardiac surgery patients. The results of the study are to identify risk factors, screen high-risk populations to improve clinical evidence, early detection and early treatment.And reducing the burden of PNCD on patients and their families, hospitals and public resources.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Non-cardiac surgery patients;
- •Age is greater than or equal to 60 years old; ③Han Nationality, mother tongue is chinese;
- •④The MMSE score:Illiteracy is greater than or equal to 17 points, primary school is greater than or equal to 20 points, higher secondary school is more than 24 points;
- •⑤The people signed informed consent.
排除标准
- •The diagnosis of preoperative delirium；
- •The diagnosis Unstable hypertension（Such as：pheochromocytoma or aortic dissection）； ③Severe chronic obstructive pulmonary disease or congestive heart failure； ④Severe liver and kidney dysfunction;
结局指标
主要结局
Confusion Assessment Method（CAM)
时间窗: afternoon of the 3st day after surgery
Confusion Assessment Method to measure delirium
次要结局
- Mini-Mental score examination (MMSE) and Neuropsychological tests(one month after surgery)
- serum branched chain amino acid content(1 day before surgery(baseline))
- Quality of Recovery Score - 40 (QoR-40)(1 day after surgery)
- serum vitamin B12 levels(1 day before surgery(baseline))
- serum homocysteine content(1 day before surgery(baseline))
- Numerical Rating Scale（NRS）(afternoon of the 3st day after surgery)
- Mini-Mental score examination (MMSE)(1 day before surgery(baseline))
- serum folic acid levels(1 day before surgery(baseline))
研究者
Han Yuan
Doctor-in-charge of Anesthetist
Xuzhou Medical University
研究点 (1)
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