A controlled clinical study on the anti microbial activity of Sarshapa arka for wound asepsis in Dushta vrana.

This study is a open label controlled clinical trial to study anti-microbial activity of Sarshapa arka for wound asepsis in Dushta vrana. Subjects are allocated into study an control groups respectively.

Study group includes 15 subjects qualifying the inclusion criteria of the current study with topical application of Sarshapa arka for 7 days continuously and collecting pre and post application swabs of wound on day 1 to check the difference in total microbial load and on day 7 to observe the changes in wound.

Control group includes 15 subjects qualifying the inclusion criteria for the current study with topical application of Povidone idone 5% solution for 7 days continuously and collecting pre and post application swabs on day 1 to check the difference in total microbial load and on day 7 to observe the changes in wound.

Primary outcome measure - 1. Total microbial load difference – Pre and post application of Sarshapa arka and Povidone Iodine 5% solution.

Secondary outcome measure - 1. Improvement in the quality of life  2.To assess any change in the wound by visual observation.

Povidone iodine 5% solution is a commonly used anti-septic agent for preoperative procedures as it is considered as an ideal disinfectant. Although a vast amount of literature exists regarding its use as a topical anti-septic agent for wound asepsis in wounds, but only few works have been done regarding its reactions and long term usage. It has few disadvantages like using it for a long run has corrosive effects, local swelling, irritation, itching and rash. It has been also reported that usage of this solution didn’t increase or decrease the infection rate.

Aqueous distillate/Arka is relatively simple method of preparation and administration, with long shelf life and is safe to use topically as distillation process itself is sterile.