Effects of Total Parenteral Nutrition on Skeletal Muscle Genomics.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Muscle protein metabolism
研究概览
简要总结
The study investigates effects related to muscle protein metabolism at provision of Total Parenteral nutrition.
详细描述
Randomized study investigating alterations in muscle protein metabolism at provision of parenteral nutrition. The study uses a genomic/transcriptomic/proteomic approach to evaluate factors related to activation of skeletal muscle protein synthesis. Patients scheduled for major gastrointestinal surgery are included. Muscle specimens are collected during surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Major gastrointestinal surgery
- •Assumed need of post-operative artificial nutrition.
排除标准
- •Insulin dependent diabetes
- •Steroid medication
研究组 & 干预措施
Total Parenteral Nutrition (TPN)
Overnight infusion of Parenteral Nutrition supplied in all-in one bag -format. Infusion-rate of 0.16 gram Nitrogen/kg/day.
干预措施: TPN (Drug)
Control (saline infusion)
Overnight infusion of physiological saline at the same infusion-rate; ml/kg as intervention (TPN).
干预措施: Control (Other)
结局指标
主要结局
Muscle protein metabolism
时间窗: Single evaluation point at 12-14 hours following the start of overnight infusion.
Alterations in muscle protein metabolism will be assessed by various standard techniques for gene and protein expression. Combined measurements of cell-signaling molecules representing anabolic and catabolic signaling pathways will be evaluated in relation to transcription of muscle myosin proteins.
次要结局
未报告次要终点