NCT02137616Unknown不适用
Effectiveness of Antipsychotic Drugs to Treat Psychosis Syndrome: an Open Label, Controlled Study
Central South University1 个研究点 分布在 1 个国家目标入组 300 人开始时间: 2012年6月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Changes of PANSS total scores from baseline to 18 months
研究概览
简要总结
This study assess the safety and effects of atypical antipsychotics in subjects with psychosis syndrome and psychosis risk syndrome.
详细描述
The investigators investigated whether administration of atypical antipsychotics could alleviate prodromal symptoms and be well tolerated by subjects with psychosis syndrome and psychosis risk syndrome.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 16 Years 至 30 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •were help-seeking young individuals in outpatients service
- •aged 16-30 years
- •fitted one of the following Criteria: Psychosis-risk Syndromes (COPS-SIPS) or Psychotic Syndrome (POPS-SIPS) or DSM-IV diagnosis of schizophreniform disorder
排除标准
- •a previous diagnosis of any psychotic disorder or bipolar disorders according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition;
- •symptoms fully accounted for by an Axis 1 disorder or sequelae of drug/alcohol use;
- •neurological disorders or organic disorders affecting the central nervous system, substance-related disorders or mental retardation as defined by the DSM-IV criteria;
- •history treatment of antipsychotic or antidepression, mood stabilizers or electroconvulsive therapy;
- •diagnosed as having a serious and unstable medical condition.
研究组 & 干预措施
risperidone
Active Comparator
low dosage of antipsychotic drug
干预措施: risperidone (Drug)
olanzapine
Active Comparator
low doseage of antipsychotic
干预措施: olanzapine (Drug)
quetiapine
Active Comparator
low doseage of antipsychotic
干预措施: Quetiapine (Drug)
aripiprazole
Active Comparator
low doseage of antipsychotic
干预措施: Aripiprazole (Drug)
结局指标
主要结局
Changes of PANSS total scores from baseline to 18 months
时间窗: 18 months
次要结局
- Social function(18 months)
- Number of Participants with Adverse Events as a Measure of Safety and Tolerability(18 months)
研究者
xiaofeng Guo
prof.
Central South University
研究点 (1)
Loading locations...
相似试验
Unknown
不适用
A Study of Antipsychotics in Individuals at Clinical High-risk for Psychosis (the SHARP-2 Study)Clinical High-riskNCT04010864Shanghai Mental Health Center600
已完成
不适用
A Randomized Double-blind Trial With 6 Antipsychotic Drugs for SchizophreniaSchizophreniaNCT02192723Beijing HuiLongGuan Hospital550
已完成
4 期
Clinical Effectiveness of Newer Antipsychotics in Comparison With Conventional Antipsychotics in SchizophreniaSchizophreniaNCT01164059University of Bremen149
已完成
4 期
Comparison of Optimal Antipsychotic Treatments for Adults With SchizophreniaSchizophreniaNCT00802100National Institute of Mental Health (NIMH)21
已完成
4 期
Effectiveness of Atypical Versus Conventional Antipsychotics in Treating SchizophreniaSchizophreniaNCT00237861Yale University