Effects of High-intensity Interval Training on Myocardial Strain in Patients With Metabolic Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 80
- 试验地点
- 2
- 主要终点
- Changes in global longitudinal strain
研究概览
简要总结
the effects of high-intensity interval training on myocardial function will be studied in a group of patients under medical treatment for the components of metabolic syndrome.
详细描述
Objective
To analyze the effects of high-intensity interval training (HIIT) on myocardial function of metabolic syndrome patients.
Methods and design. Randomized clinical trial with a control group. Project was developed in association with the regional general hospital. Pre and post-intervention evaluation after 16 weeks of training for the HIIT group.
Subjects: Recruited using adverts published on public medical center boards. Up to 30 subjects per group (HIIT and CONTROL) will be recruited (at least 20% women) Measurements. Echocardiography: Global longitudinal strain (GLS), Mitral filling parameters, myocardial dimensions, and myocardial wall thickness.
Cardiorespiratory fitness: Maximal oxygen consumption, Maximal power output, Maximal oxygen pulse.
Clinical: Metabolic syndrome components and derived variables (e.g., triglycerides/high-density lipoprotein ratio) Body composition by anthropometric measurements and dual-energy X-ray absorptiometry.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
盲法说明
Echocardiography evaluators will be masked about participant allocation.
入排标准
- 年龄范围
- 30 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of metabolic syndrome.
- •Capacity to exercise on a stationary bike
- •Inhabitant of the province of Toledo
排除标准
- •Untreated cardiovascular disease with hemodynamic instability
- •Untreated respiratory disease, symptomatic.
- •Untreated metabolic disease.
- •Untreated renal disease requiring dialysis.
- •Contraindications for high-intensity exercise training
结局指标
主要结局
Changes in global longitudinal strain
时间窗: up to 16 weeks
response to myocardial strain after intervention. Assessed by echocardiography, measured as a percentage
次要结局
- changes in cardiorespiratory fitness(up to 16 weeks)
- changes in metabolic syndrome z-score(up to 16 weeks)
- changes in estimated left ventricle filling pressures (E/e')(up to 16 weeks)
- changes in visceral fat(up to 16 weeks)
- changes in left ventricle passive filling (E wave)(up to 16 weeks)
- changes in early diastolic mitral annulus velocity (e' wave)(up to 16 weeks)