Epidemiology and Outcome of Ventilator-associated Pneumonia Among Critically Ill COVID-19 Patients
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- 28-day all-cause mortality
研究概览
简要总结
The aim of this study is to determine the risk factors for development of ventilator-associated pneumonia (VAP) and to identify the prognostic factors of VAP among Coronavirus Disease 2019 (CoViD-19) patients. We hypothesized that CoViD-19 serves as a high risk factor for the development of VAP and it affects clinical outcome measures negatively.
详细描述
Coronavirus Disease 2019 (CoViD-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became a pandemic affecting thousands of individuals worldwide. A considerable proportion of CoViD-19 patients require admission to the intensive care unit (ICU), although limited data are available on their clinical characteristics and course. The results of retrospective studies indicate older age, presence of comorbidies and secondary infections as predictors of mortality among this population. Further evaluation regarding ICU clinical course and predictors of mortality is needed.
The aim of this study is to determine the risk factors for development of VAP and to identify the prognostic factors of VAP among CoViD-19 patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Critically ill individuals diagnosed with PCR confirmed CoViD-19 disease
- •Started mechanical ventilation for > 48 hours
- •Informed consent signed by the patient or authorised representative
排除标准
- •Participation in an interventional trial aiming nosocomial infections
- •refused informed consent
结局指标
主要结局
28-day all-cause mortality
时间窗: at study completion, anticipated 5 months
次要结局
- ICU length-of-stay(average time frame expected 3-4 weeks)
- Days of mechanical ventilation(average time frame expected 2-3 weeks)
- Antibiotic utilization(average time frame expected 3-4 weeks (at discharge from ICU))
- Ventilator-associated pneumonia rate(at study completion, anticipated 5 months)
研究者
Zsolt Iványi
Associate Professor
Semmelweis University