Alteration in Fibrinogen Metabolism in Patients With Severe Burns and Traumatic Injuries
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 主要终点
- During the flow phase following burn or trauma injury, fibrinogen degradation is accelerated
研究概览
简要总结
To study the fibrinogen metabolic changes in relation to coagulation disorder in patients with severe burns and trauma injuries. As a result of the burn or trauma injury breakdown of fibrinogen is accelerated.
详细描述
In this protocol, we will investigate fibrinogen metabolism in burn and trauma patients, using an 8h infusion of stable isotopes labeled amino acids (1-13C-phenylalanine, 2H5-phenylalanine, and 2H3-ketoisocaporate). The increase of the labeled amino acids incorporating into fibrinogen during the infusion and the decay of labeled fibrinogen after stopping the isotopes infusion (as measured by GC-MS) will be used to calculate fibrinogen synthesis and degradation. Stable isotopes are non-radioactive.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •20% total body surface area burn or more
- •severe trauma with injury severity score greater than 10
- •between ages of 18 and 65 years
排除标准
- •history of blood clotting disorder
- •history of liver disease such as cirrhosis or hepatitis
- •pregnant or nursing
- •allergic to iodine, shellfish or dye used in X-Rays
- •taking long term medications for blood clotting usch as Coumadin or Plavix
- •prisoners
- •receiving total parenteral nutrition
结局指标
主要结局
During the flow phase following burn or trauma injury, fibrinogen degradation is accelerated
时间窗: 7
次要结局
- Fibrinogen degradation stimulates fibrinogen synthesis at the expense of whole body protein catabolism(7 days)