Systemic antibiotic therapy (amoxicillin plus metronidazole) as an adjunct to initial non-surgical treatment of peri-implantitis; a single blind randomized controlled study - Systemic amoxicillin plus metronidazole in peri-implantitis treatment

niversitair Medisch Centrum Groningen0 个研究点目标入组 60 人开始时间: 待定最近更新: 2024年4月29日

适应症

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•1) The patient is >= 18 years of age;
•2) The patient has at least one endosseous implant in the oral cavity with clinical and radiographical signs of peri-implantitis. Peri-implantitis is defined as a loss of marginal bone >= 2 mm as compared to the shoulder of the implant (the level at which the bone is normally located immediately after implant placement), in combination with bleeding and/or suppuration on probing and a peri-implant probing depth >= 5 mm; ;3) The implants have been in function for at least two years;;4) The patient is capable of understanding and giving informed consent.

•1) Medical and general contraindications for the surgical procedures;
•2) A history of local radiotherapy to the head and neck region;
•3) Pregnancy and lactation;
•4) Uncontrolled diabetes (HbA1c < 7% or < 53 mmol/mol)
•5) Mononucleosis infectiosa
•6) Organic neurological disorders
•7) Use of antibiotics during the last 3 months;
•8) Known allergy to amoxicillin, metronidazole or chlorhexidine;
•9) Long-term use of anti-inflammatory drugs;
•10) Full edentulism (no remaining teeth, only implants)
•11) Incapability of performing basal oral hygiene measures as a result of physical or mental disorders;
•12) Implants placed in areas augmented with autogenous bone from the crista iliac region;
•13) Implants placed in skin grafted areas;
•14) Implants with bone loss exceeding 2/3 of the length of the implant or implants with bone loss beyond the transverse openings in hollow implants;
•15) Implant mobility;
•16) Implants at which no position can be identified where proper probing measurements can be performed;
•17) Previous surgical treatment of the peri-implantitis lesions;
•18) Previous non-surgical treatment of the peri-implantitis lesions during the last 6 months (scaling or curretage).

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