NCT00484146终止不适用
Alterations of Immunologic Mediators During Severe Sepsis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- severity of sepsis
研究概览
简要总结
Severe sepsis induces significant changes in expression of insulin- and toll-like receptors, cytokines, markers of apoptosis, and activation of t- and b-lymphocytes.
详细描述
In patients at early stage of severe sepsis, we investigate the expression of pro- and anti-inflammatory cytokines, chemokines, adhesion-molecules, toll-like receptors, insulin-receptors, markers of apoptosis und of t- and b-cell-activation on a mRNA level.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age >= 18 y
- •agreement with study procedures
- •3 of 4 SIRS-criteria
- •proven or highly suspected infection
- •2 or more sepsis-induced organ failures
- •start of first sepsis-induced organ failure within the last 36 hours
排除标准
- •non-agreement with study procedures
- •signs of severe sepsis with organ failure > 36 hours
- •chronic immuno-compromising diseases
- •chronic therapy with anti-inflammatory drugs
- •non-curable cancer
- •chronic renal failure with hemodialysis
- •pregnancy or breast-feeding
结局指标
主要结局
severity of sepsis
时间窗: 96 hours after diagnosis of sepsis
SOFA-Score
次要结局
未报告次要终点
研究者
Armin Sablotzki, MD
Prof. Dr. med.
Klinikum St. Georg gGmbH
研究点 (1)
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