Molecular Characterization of Lung Cancer: A Collaboration With the Cancer Genome Atlas Project (TGCA)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 248
- 试验地点
- 11
- 主要终点
- Identification and characterization of SNVs in primary adenocarcinoma of the lung or squamous cell carcinoma of the lung
研究概览
简要总结
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research trial studies tissue samples from patients with non-small cell lung cancer.
详细描述
OBJECTIVES:
- To identify and characterize single nucleotide variations (SNVs) in non-small cell lung cancer (NSCLC) specimens.
- To identify and characterize structural variations in the genomes of NSCLC specimens.
- To identify and characterize other genomic alterations including, but not limited to, expression profiling and methylation.
OUTLINE: DNA and RNA extracted from archived specimens are analyzed for single nucleotide variations, structural variations in the genomes, and other genomic alterations including, but not limited to, gene expression profiling and methylation. Clinical data related to disease, treatment, and recurrence from each patient sample is also collected.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Identification and characterization of SNVs in primary adenocarcinoma of the lung or squamous cell carcinoma of the lung
时间窗: up to 5 years
Identification and characterization of structural variations in the genomes of NSCLC
时间窗: up to 5 years
Identification and characterization of other genomic alterations including, but not limited to, gene expression profiling and methylation
时间窗: up to 5 years
次要结局
未报告次要终点