Electroencephalogram Studies of Induction and Recovery From Propofol Induced General Anesthesia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- EEG Power in Alpha, Slow, and Delta Bands
研究概览
简要总结
The purpose of this study is to investigate how the commonly used anesthetic drug propofol works in the brain to produce loss of consciousness. While under general anesthesia your brain waves will be measured using electroencephalogram (EEG). On a separate day, the patient's brain will be imaged using magnetic resonance imaging (MRI).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 36 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy, non-smoking male and female volunteers, ages 18-36 with normal body weight.
- •American Society of Anesthesiologists (ASA) physical status I
排除标准
- •History of head trauma
- •Surgical aneurysm clips
- •Cardiac pacemaker
- •Prosthetic heart valve
- •Neurostimulator
- •Implanted pumps
- •Cochlear implants
- •Metal rods, plates
- •Intrauterine device
- •Hearing aid
- •Dentures (which might create NMR artifacts)
- •Metal injury to eyes
研究组 & 干预措施
Active Study Arm
Subjects recruited into this study will be required to undergo a base MRI scan of the brain. On a separate day propofol will be administered with concurrent EEG while subjects respond to stimuli.
干预措施: Propofol (Drug)
结局指标
主要结局
EEG Power in Alpha, Slow, and Delta Bands
时间窗: 11 hours
We used EEG measurements to study the dynamics of loss of consciousness, auditory processing, sensation, and memory under general anesthesia induced with propofol. The EEG data in each of the three specific aims will be analyzed using spectral methods, source localization, and event-related potentials. Through spectral analysis, EEG power (in decibels) in alpha, slow, and delta bands are measured.
次要结局
未报告次要终点
研究者
Emery Brown
Emery N. Brown, M.D., Ph.D.
Massachusetts General Hospital