NL-OMON53264招募中不适用
High Flow Nasal Oxygen For Hypercapnic, Acidotic Exacerbation Chronic Obstructive Pulmonary Disease. (HicaP) - HFNO in COPD
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Known chronic obstructive pulmonary disease
- •Acute hypercapnic exacerbation of this condition, defined as:
- •o PaCO2>45 mmHg or >6.0 kPa
- •o pH 7.25-7.34
- •Age >40 years
排除标准
- •- Metabolic (component of) acidosis, defined as a bicarbonate <20 mmol/L.
- •- Non-invasive respiratory support (either NIV or HFNO) already started, e.g.
- •by ambulance or on the ward.
- •Immediate need for intubation, based on clinical judgement of the attending
- •Impossibility to apply either one of the two interventions
- •Patient not expected to give immediate or delayed informed consent (e.g.
- •cognitive impairment, psychological or mental inabilities).
- •Established home-NIV or home CPAP, known indication for home-NIV or CPAP
- •(e.g. OSAS or obesitas hypoventilation syndrome).
- •Impeding death
- •Concurrent (respiratory) diseases that may influence treatment efficacy:
- •acute heart infarction, cardiogenic lung edema, massive pulmonary embolism
- •(intermediate-high risk or more). NB; pulmonary infections (viral and
- •bacterial) are a common cause of exacerbation and are no reason for exclusion.
- •Other acute diseases that preclude participation in the trial such as
- •hemodynamic instability (need for vasopressors), reduced consciousness with
- •need for intubation, severe intoxication
- •Tracheostomized patients
- •Participation in other interventional trials
- •Impossibility to admit the patient to the participating ICU or monitored ward
- •(e.g. medium care / high dependency unit, depending on local infrastructure).
研究者
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