To build a precise diagnosis and treatment system for membranous nephropathy based on the correlation between intestinal microecology and TCM tongue diagnosis

onghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine0 个研究点开始时间: 待定最近更新: 2023年2月20日

试验速览

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•1. Diagnosed as primary membranous nephropathy by renal biopsy and clinical examination;
•2. Aged 18-75 years old;
•3. CKD<=3 stage (GFR>30ml/min), 24-hour urine protein quantitative >=1g;

•1. Rapidly progressive membranous nephropathy (progressive decline in renal function, necrotizing capillary vasculitis and >50% large crescent formation on renal biopsy);
•2. Membranous nephropathy with IgA nephropathy;
•3. Have received immunosuppressive drugs or cytotoxic drugs for more than 4 weeks in the past 6 months;
•4. Have received glucocorticoids (prednisone or prednisone) at a dose of more than 20 mg/d for more than 4 weeks in the past 6 months;
•5. Combined with life-threatening complications such as severe infection;
•6. Those with positive HBV serological indicators other than HbsAb and those with abnormal transaminase in continuous liver function tests;
•7. Patients with malignant tumors or patients with malignant tumor history, history of HIV infection, history of mental illness, acute central nervous system disease, severe gastrointestinal disease, and patients who are prohibited from using immunosuppressive agents;
•8. Abnormal glucose metabolism, fasting blood sugar exceeding 6.2mmol/L;
•9. Pregnant or lactating women;
•10. Undergoing other clinical trial research;
•11. Combined with serious diseases and dysfunction of other organs;
•12. Taking probiotics for treatment in the past month;
•13. The blood pressure of hypertension is controlled at 130/80mmHg.

发起方

onghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine