Predictive Value of CHA2DS2-VASC Score and Contrast Volume to Creatinine Clearance Ratio in Relation to Mehran Score for Contrast-Induced Nephropathy In ST- Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention
试验速览
- 阶段
- 不适用
- 入组人数
- 210
- 试验地点
- 1
- 主要终点
- Contrast induced nephropathy
研究概览
简要总结
all patient presented with ST elevated myocardial infarction and underwent PPCI will be calculated with CHA2DS2-VASC score and contrast volume / creatinine clearance as apredictive value for Contrast induced nephropathy and the predictive value of these scores will be compared with the approved predictive value of MEHRAN score which is also will be calculated to every patient .
详细描述
Myocardial infarction is a major cause of death and disability worldwide. Coronary reperfusion with primary percutaneous coronary intervention ( PPCI) or fibrinolytic therapy improves outcomes in patients with acute ST elevation myocardial infarction (STEMI).
PPCI can be defined as coronary angioplasty/stenting without prior administration of fibrinolytic agents or GPIIb/IIIa antagonists. These patients are usually treated with aspirin, a loading dose of clopidogrel together with heparin or bivalirudin, before the intervention.
If PPCI is performed promptly, the procedure is superior to fibrinolysis in restoring flow to the infarct-related artery in patients with STEMI.
Current guidelines for the treatment of STEMI recommend a door-to-balloon time of 90 minutes or less for patients undergoing PPCI. Door-to-balloon time has become a performance measure and is the focus of regional and national quality-improvement initiatives.
The contrast induced acute kidney injury has commonly been referred to as contrast induced nephropathy (CIN) defined as an increase in serum creatinine ≥25% or ≥0.5 mg/dl from baseline within 48-72 h after contrast exposure. (Weisbord, et al 2006.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients with STEMI who are eligible for primary PCI will be enrolled in the study.
排除标准
- •(1) If the coronary anatomy was not suitable for PCI. (2) If emergency bypass grafting was required. (3) Patients in chronic peritoneal or hemodialytic treatment.
结局指标
主要结局
Contrast induced nephropathy
时间窗: 48 hours
contrast induced nephropathy (CIN) defined as an increase in serum creatinine ≥25% or ≥0.5 mg/dl from baseline within 48 h after contrast exposure so we will follow up creatinine level according to the defenition .
次要结局
未报告次要终点
研究者
ghada morsy
resident at cardiology department at assiut university hospital
Assiut University