Comparison of the Effects of Sevoflurane and Desflurane Used for Anesthesia Maintenance on Optic Nerve Sheath Diameter in the Trendelenburg Position
概览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- Medipol University
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Optic Nerve Sheath Diameter (ONSD)
概览
简要总结
Laparoscopic surgeries require pneumoperitoneum and Trendelenburg position, which may lead to increased intracranial pressure (ICP).
Optic nerve sheath diameter (ONSD) measurement via ultrasound is a non-invasive method to evaluate ICP.
This prospective study aims to compare the effects of sevoflurane and desflurane on ONSD in patients undergoing laparoscopic hysterectomy and bilateral oophorectomy in the Trendelenburg position.
详细描述
The primary objective of this study is to compare the ONSD values measured by ultrasound between the sevoflurane and desflurane groups.
The secondary objective is to evaluate the relationship between ONSD changes, hemodynamic parameters, and postoperative neurological complications.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patients planned for laparoscopic hysterectomy bilateral oophorectomy surgery under general anesthesia.
排除标准
- •Patients receiving beta-blocker or diuretic treatment.
- •Patients with severe heart failure.
- •Patients diagnosed with diabetes with ocular or neurological complications.
- •Patients who have undergone cardiac surgery, eye surgery, brain surgery, or thoracic surgery.
- •Patients with a history of hydrocephalus, glaucoma, intracranial mass, and stroke.
研究组 & 干预措施
Group 1 (Sevo)
干预措施: Sevoflurane (Drug)
Group 2 (Des)
干预措施: Desflurane (Drug)
结局指标
主要结局
Optic Nerve Sheath Diameter (ONSD)
时间窗: Intraoperative (approx. 2-4 hours): immediately and 10 min post-intubation, 10 and 60 min post-Trendelenburg/pneumoperitoneum, 10 min post-neutral position."
Three measurements will be taken in the transverse and sagittal planes for each eye and the average will be calculated.
次要结局
- Heart Rate (HR)(Intraoperative (approx. 2-4 hours): immediately and 10 min post-intubation, 10 and 60 min post-Trendelenburg/pneumoperitoneum, 10 min post-neutral position.")
- Mean Arterial Pressure (MAP)(Intraoperative (approx. 2-4 hours): immediately and 10 min post-intubation, 10 and 60 min post-Trendelenburg/pneumoperitoneum, 10 min post-neutral position.")
- Peripheral Oxygen Saturation (SpO2)(Intraoperative (approx. 2-4 hours): immediately and 10 min post-intubation, 10 and 60 min post-Trendelenburg/pneumoperitoneum, 10 min post-neutral position.")
- End-tidal Carbon Dioxide (EtCO2)(Intraoperative (approx. 2-4 hours): immediately and 10 min post-intubation, 10 and 60 min post-Trendelenburg/pneumoperitoneum, 10 min post-neutral position.")
- Arterial pH(Intraoperative (approx. 2-4 hours): immediately and 10 min post-intubation, 10 and 60 min post-Trendelenburg/pneumoperitoneum, 10 min post-neutral position.")
- Partial Pressure of Carbon Dioxide (pCO2)(Intraoperative (approx. 2-4 hours): immediately and 10 min post-intubation, 10 and 60 min post-Trendelenburg/pneumoperitoneum, 10 min post-neutral position.")
研究者
Burak Omur
assistant professor
Medipol University