EUCTR2013-000189-12-NL进行中（未招募）不适用
Effects of the selective mineralocorticoid receptor antagonist eplerenone on extracellular formation of adenosine - eplerenone and adenosine
niversity Medical Centre Nijmegen0 个研究点开始时间: 2013年3月8日最近更新:
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- Male
入选标准
- •male sex, age 18-40 years, healthy, written informed consent
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range 14
- •F.1.3 Elderly (>=65 years) no
- •F.1.3.1 Number of subjects for this age range
排除标准
- •potassium >4.8 mmol/L, smoking, hypertension (SBP >140 or DBP >90 mmHg), hypotension (SBP <100 or DBP <60 mmHg), diabetes mellitus (fasting glucose >7.0 mmol/L or random >11.0 mmol/L), history of any cardiovascular disease, angina pectoris, history of COPD or asthma, alcohol and/or drug abuse, concomitant use of medication, renal dysfunction (MDRD <60 mL/min), liver enzyme abnormalities (ALAT >twice upper limit), fasting total cholesterol >6 mmol/L, 2nd/3rd degree AV block on electrocardiography. During the study a serum potassium of >5.2 mmol/L is an exclusion criterium.
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