Effect of Agave Consumption on Performance and Gut Microbiota in Adults Undergoing Physical Training
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Changes in the relative abundance of gut microbiota bacterial taxa determined by multiplex digital PCR
研究概览
简要总结
The purpose of this study is to analyze changes in the gut microbiota of healthy adult athletes, both men and women, before and after supplementation with a dietary fiber (agavins). Each participant will be their own control, so the design will allow us to identify whether the intervention generates changes in bacterial composition and whether these changes are related to variations in physical performance.
The study will determine changes in the gut microbiota, athletic performance, and markers of metabolic stress such as lactate and creatine kinase.
Volunteers will be required to take 10g of agavins in warm water for 6 weeks.
The gut microbiota will be evaluated through a stool sample, while athletic performance will be measured through direct calorimetry, determining VO2max. Lactate will be determined by finger prick using Accutrend Plus equipment, while creatine kinase will be measured using a blood sample taken by staff from the biomarker measurement laboratory of the Department of Nutrition and Functional Foods.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •athletes in any sport, metabolically healthy.
排除标准
- •intestinal diseases, recreational athletes, people undergoing antibiotic treatment, people undergoing treatment with probiotics or prebiotics.
研究组 & 干预措施
agavins
Intervention group that is its own control
干预措施: Agavins (Dietary Supplement)
结局指标
主要结局
Changes in the relative abundance of gut microbiota bacterial taxa determined by multiplex digital PCR
时间窗: Before and after agavin supplementation, which lasts 6 weeks
The relative abundance of selected gut microbiota bacterial taxa will be determined from fresh fecal samples collected at baseline and after 6 weeks of supplementation using multiplex digital PCR and reported as percentages of the total bacterial population.
次要结局
- Changes in metabolic stress markers (serum creatine kinase and blood lactate concentrations)(Before and after agavin supplementation, which lasts 6 weeks)
- Change in maximal oxygen consumption (VO₂max; mL/kg/min)(before and after the agave treatment, which lasts 6 weeks)
- Change in body composition(before and after the intervention, which lasts six weeks)
研究者
AMALINALI PORTILLO AYALA
phD student
National Polytechnic Institute, Mexico