Effects of Resistance and Endurance Training on Synthesis of Individual Muscle Proteins in Young and Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 67
- 试验地点
- 2
- 主要终点
- Skeletal Muscle Protein Synthesis
研究概览
简要总结
Loss of skeletal muscle strength and skeletal muscle mass occurs with of aging. This are-related decline in skeletal muscle mass and skeletal muscle strength is a major underlying factor contributing to many of the metabolic disorders and frailty of the investigators rapidly expanding aging population. Endurance (aerobic) and resistance exercise training programs have been shown to effectively reverse the age-related decline in metabolic and contractile muscle functions. The investigators will measure synthesis rates of individual muscle proteins in 36 each of young (18-30 yrs) and 36 older (> 65 yrs) people to determine their response to 8 weeks each of endurance, resistance, combined endurance and resistance training, or placebo exercise training.
Hypotheses.
- to measure fractional synthesis rates of multiple muscle proteins and identify those that are enhanced by an endurance exercise program
- to determine whether changes in protein synthesis in response to endurance exercise programs are dependent on age
- to measure fractional muscle synthesis rates of multiple muscle proteins and to identify those that are enhanced by a resistance exercise program
- to determine whether changes in protein synthesis in response to resistance exercise programs are dependent on age
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18 to 30 or >65 years
- •Males and Females
排除标准
- •Regular Exercise Program
- •Cardiometabolic Disease (diabetes, cardiovascular disease, thyroid disorders)
- •Drugs known to impair metabolic function (beta blockers, steroids)
- •Allergies to lidocaine
- •Physical disability that precludes exercise
结局指标
主要结局
Skeletal Muscle Protein Synthesis
时间窗: Measured at week 0 (baseline) and week 8
The investigators will determine the change from baseline in skeletal muscle protein synthesis. Measurments will be performed at baseline and following 8 weeks of exercise training.
次要结局
- Mitochondrial Function(Measured at week 0 (baseline) and week 8)
研究者
K. Sreekumaran Nair
Professor of Medicine
Mayo Clinic