Sildenafil Citrate for Endometrial Preparation in Frozen-thawed Embryo Transfer Cycles
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 90
- 主要终点
- endometrial pattern
研究概览
简要总结
Comparison between usage of Sildenafil citrate with estradiol valerate or estradiol valerate alone in endometrial preparation and outcome of frozen-thawed embryo transfer cycles.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 37 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •all cases have at least 2 good quality blastocysts available for transfer
排除标准
- •uterine structural abnormalities
- •advanced uterine disease
- •hydrosalpinx and pyosalpinx
研究组 & 干预措施
estradiol valerate
estradiol valerate 2mg every 12 hours orally starting from the second day of the menstrual cycle till reaching trilaminar endometrial pattern and endometrial thickness 8 mm or more
干预措施: estradiol valerate (Drug)
Sildenafil citrate and estradiol valerate
Sildenafil citrate 25 mg every 6 hours orally in combination with estradiol valerate 2mg every 12 hours orally starting from the second day of the menstrual cycle till reaching trilaminar endometrial pattern and endometrial thickness 8 mm or more
干预措施: Sildenafil citrate (Drug)
Sildenafil citrate and estradiol valerate
Sildenafil citrate 25 mg every 6 hours orally in combination with estradiol valerate 2mg every 12 hours orally starting from the second day of the menstrual cycle till reaching trilaminar endometrial pattern and endometrial thickness 8 mm or more
干预措施: estradiol valerate (Drug)
结局指标
主要结局
endometrial pattern
时间窗: starting from 8th day till 12th day of the menstrual cycle
Endometrial pattern will be trilaminar or bilaminar after it's preparation with estradiol valerate alone or estradiol valerate and sildenafil citrate. Endometrial pattern will be estimated by transvaginal ultrasonography for trilaminar pattern every other day from 8th day till 12th day of the menstrual cycle.
次要结局
- endometrial thickness(starting from 8th day till 12th day of menstrual cycle)
- biochemical pregnancy test(2 weeks after embryo transfer)
研究者
Omar Ahmed El Sayed Saad
Resident of obstetric and gynecology in Shebin Elkom teaching hospital
Ain Shams Maternity Hospital