NCT04107883Unknown不适用
Effect of Transfusion of Plasma During Orthotopic Liver Transplantation on Endothelial Glycocalyx Layer and Short-term Outcome in Patients With End-Stage Liver Disease
Beijing Chao Yang Hospital1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2023年10月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- endothelial glycocalyx layer shedding markers
研究概览
简要总结
To study the effects of plasma transfusionon during liver transplantation on endothelial condition and short-term outcome in patients with end-stage liver disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Child A/B cirrhosis
- •patients who undergo the first OLT
- •Informed and consented
- •complete follow-up
- •cooperate with treatment
排除标准
- •re-transplant
- •combined liver and other organ transplantation
- •BMI≥30Kg/m2
- •patients with hypertension, diabetes, coronary heart disease, chronic renal insufficiency, preoperative pulmonary infection, pleural effusion
- •acute liver failure
结局指标
主要结局
endothelial glycocalyx layer shedding markers
时间窗: 24 hours
plasma concentration of endothelial glycocalyx layer shedding markers
次要结局
- inflammatory cytokines(24 hours)
研究者
Xun Liu
Principal Investigator
Beijing Chao Yang Hospital
研究点 (1)
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