CTRI/2015/01/005425已完成不适用
Comparision of effect of desflurane and propofol on postoperative cognitive dysfunction in patients undergoing aneurysm neck clipping after sub arachnoid haemorrhage
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- comparision of POCD between study group desflurane and propofol postoperatively
研究概览
简要总结
Anaesthesiologist commonly use TIVA or inhalational agent in aneurysmal surgery. There is no randanmised trial comparing their effects in SAH patients undergoing craniotomy and clipping surgery.Both propofol and desflurane have the advantage of fast awakening and are popularin neurosurgical practice. Hence, this study is designed to prospectively evaluate the effects of propofol and desflurane on POCD in patients of aSAH undergoing craniotomy and clipping of aneurysmal neck.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Inclusion Criteria (1)Patients scheduled for aSAH surgery with clinical and radiological evidence of cerebral aneurysm.
- •(2)Age between 18 to 65 yrs.
- •(3)H and H grade 1 ,2 & 3 and WFNS grade 1, 2 &
- •(4)ASA 1, ASA 2 and ASA 3 will be included.
排除标准
- •Exclusion Criteria (1)Patients with systemic disease other than hypertension and diabetes mellitus.
- •(2) Patients with infectious diseases and respiratory complications.
- •(3) Duration of anesthesia more than six hours.
- •(4) Second operation.
- •(5) Low level of education.
- •(6) Patients with known psychiatric disease.
- •(7) Cardiovascular disease and respiratory impairment.
- •(8) History of drug abuse.
- •(9) Known allergy to any of the anesthetic agent to be used in study.
- •(10)Patients who are unconscious, intubated or tracheostomised even after two weeks following exposure to anesthesia will also be excluded from the study.
结局指标
主要结局
comparision of POCD between study group desflurane and propofol postoperatively
时间窗: MOCA score 0 to 30
次要结局
- comparision of haemodynamics and brain bulge between study groups desflurane and propofol intraoperatively(brain bulge score 0 to4)
研究者
研究点 (1)
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