The Effect of Early Prone Position on Prognosis in Acute Respiratory Failure Due to Coronavirus Disease 2019 Pneumonia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 33
- 试验地点
- 1
- 主要终点
- short term mortality
研究概览
简要总结
the purpose of this study to evaluate the effect of early awake PP (prone position)application on oxygenation and intubation requirement in patients with acute respiratory failure due to coronavirus disease 2019 pneumonia.
详细描述
The first group (early prone position-EPP) created for our study was composed of patients who received PP at least 12 hours early (with the first 48 hours) with the oxygen support of the reservoir mask, and the second group (non-EPP ) patients who received oxygen with the reservoir mask but could not be applied early PP due to the patient's incompatibility or rejection.
Conventional oxygen therapy applied to all patients was given with a reservoir mask, aiming at oxygen saturation 93% and above, at a flow rate of 6-15 L / min.
Despite all the treatments, the patients who have a follow-up with a respiratory acidosis , oxygen saturation value below 93%, applied non invasive mechanical ventilation, in case of insufficient patient intubated and have invasive mechanical ventilation. In patients who had regression of glasgow coma scale during follow-up, orotracheal intubation was performed and invasive mechanical ventilation was performed.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who developed acute respiratory failure due to coronavirus disease 2019 pneumonia
- •received conventional oxygen therapy with reservoir mask oxygen at the stage of admission to the intensive care unit
- •older than 18 years old
排除标准
- •patients with respiratory acidosis,
- •partial oxygen pressure/fraction of inspired oxygen ratio below 150,
- •Glasgow Coma Score (GKS) below 12 points,
- •hemodynamic instability,
- •primary pulmonary pathologies other than pneumonia (lung cancer, cardiopulmonary edema, carcinogen syndrome, etc.)
- •patients who underwent non-invasive mechanical ventilation(NIMV) or intubated from admission to intensive care,
- •those who underwent self prone position under 12 hours were not included in the study.
结局指标
主要结局
short term mortality
时间窗: up to 28 days
mortality percent
intensive care unit stay
时间窗: up to 28 days
the duration of icu stay day
次要结局
- blood gases(up to 24 hours)
研究者
Mustafa Altınay
spercialist medical doctor
Sisli Hamidiye Etfal Training and Research Hospital