NCT05629832已完成不适用
Transpulmonary Pressure Guided Mechanical Ventilation Strategy for Right Ventricle Protection in Acute Respiratory Distress Syndrome
Beijing Chao Yang Hospital1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2023年1月1日最近更新:
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Pulmonary vascular resistance (PVR)
研究概览
简要总结
To compare the effect between mechanical ventilation strategy guided by transpulmonary pressure and tranditional lung protective ventilation strategy in acute respiratory distress syndrome for right ventricle protection.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •duration of invasive mechanical ventilation less than 72 hours;
- •meet the diagnostic criteria of Berlin definition for ARDS;
- •age older than 18
排除标准
- •esophageal surgery or damage;
- •cardiac surgery;
- •severe bronchopleural fistula;
- •serious arrhythmia; pneumothorax;
- •tricuspid stenosis;
- •heparin allergy;
- •chronic pulmonary heart disease
研究组 & 干预措施
PTP group
Experimental
干预措施: mechanical ventilation strategy guided by transpulmonary pressure (Procedure)
Control group
No Intervention
结局指标
主要结局
Pulmonary vascular resistance (PVR)
时间窗: 3 days
PVR will measured by Swan-Ganz catheter
Pulmonary vascular compliance
时间窗: 3 days
Pulmonary vascular compliance will be calculated using pulmonary artery pressure divided by stroke output measured by Swan-Ganz catheter.
次要结局
未报告次要终点
研究者
Xiao Tang
Doctor
Beijing Chao Yang Hospital
研究点 (1)
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