The New Biochemical Markers of Cardiac Surgery Related Acute Kidney Injury.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 88
- 试验地点
- 1
- 主要终点
- acute kidney injure after operation
研究概览
简要总结
Cardiac surgery related acute kidney injury (CS-AKI) is a clinical problem associated with a cardiopulmonary bypass used during cardiac surgery procedures. In this study the investigators will assess the biochemical markers of acute kidney injury such as ischemia modified albumin (IMA) or urinary excreted of brush-border enzymes of the proximal renal tubules perioperatively. There has been no official recommendations toward routine use of analysed biomarkers.
详细描述
Cardiac surgery related acute kidney injury (CS-AKI) is an important clinical problem. Kidney injury occurs following a cardiopulmonary bypass used during cardiac surgery procedures. The pathomechanisms of acute kidney injury (AKI) is complex and multifactorial. It may involve few injury pathways: ischemia and reperfusion, endogenous toxins, inflammation, metabolic factors and oxidative stress. Biochemical markers of acute kidney injury such as ischemia modified albumin (IMA) or urinary excreted of brush-border enzymes of the proximal renal tubules analysed perioperatively will be assessed in this study. There has been no official recommendations toward routine use of analysed biomarkers.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •a planned operation of coronary artery bypass grafting with the use of cardiopulmonary bypass
排除标准
- •emergency operations or re-operations;
- •a known pathology of the urinary tract or renal failure;
- •chronic use of the following medications: iron, non-steroidal anti-inflammatory drugs (NSAIDs), immunosuppression, or steroids in the preoperative period;
- •polycythemia, porphyria or pathological hemoglobin species in anamnesis;
- •preoperative signs of hepatic failure;
- •active autoimmune or neoplastic diseases, active infection;
- •anticipated significant bleeding (anti-platelet agents), suggesting the use of blood-derived products during the operation and afterward
- •acute myocardial infarction after operation
结局指标
主要结局
acute kidney injure after operation
时间窗: up to 48 hours post operation
acute kidney injure measured by urine output in ml
次要结局
未报告次要终点
研究者
Jowita Biernawska
MD PhD
Pomeranian Medical University Szczecin