An 8 Week Study to Compare the Effects of Two Combinations of Water Soluble and Non-water Soluble Cod Residual Meals on Glucose Regulation in Overweight and Obese Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 55
- 试验地点
- 1
- 主要终点
- Glucose tolerance
研究概览
简要总结
The investigators have previously shown the intact protein from cod filet improves glucose regulation and serum lipid profile in overweight adults. A large amount of trimmings from various fish species such as cod is thrown away or sold at very low prices for animal feed, and analyses of the amino acid composition reveals that this can be a good protein source for humans. Two fractions are normally isolated from intact fish meal, i.e. water soluble and non-water soluble proteins. In the present study the investigators will compare these fractions, by studying their effects on glucose regulation in overweight/obese adults.
详细描述
Participants receive 6g per day of water soluble on non-water soluble cod protein as tablets for 8 weeks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •fasting blood glucose <7.0 mmol/L
- •stable body weight with less than 5 kg fluctuation during the last 4 months
排除标准
- •known disease or metabolic disturbances related to overweight or obesity
- •use of prescription medications that affect blood glucose, blood lipids or inflammatory status
- •allergies towards fish or seafood
- •undertaking a weight loss diet
- •tobacco use exceeding >15 cigarettes/day
- •pregnancy or breastfeeding
- •high seafood consumption
- •use of dietary supplements including cod liver oil or other marine fatty acids
- •allergies towards fish, milk, egg
结局指标
主要结局
Glucose tolerance
时间窗: 8 weeks
Serum glucose will be measured in fasting and postprandial state
次要结局
- Comparisons of metabolites and co-factors involved in one-carbon metabolism in serum and urine(8 weeks)
- Gene expression(8 weeks)
- Amino acids and amino acid metabolites(8 weeks)
研究者
Oddrun Anita Gudbrandsen
PhD
University of Bergen