Timing (AM v PM) of Acute Resistance Exercise on Glycemic Control in Older Adults: The Acute T-Rex Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Insulin sensitivity
研究概览
简要总结
The primary aim of this study is to evaluate if a single bout of AM vs PM resistance exercise has different effects on insulin sensitivity and sleep. A randomized cross-over trial be used to compare resistance exercise at two different times of the day. Each condition will take place in a laboratory setting. Each condition will consist of exercise, overnight sleep, and oral glucose tolerance tests the following day. The AM exercise will occur ~1.5 hours after habitual wake, and PM exercise will occur ~11 hours after habitual wake. After a 2-6 week washout, participants will complete the other condition. The hypothesis is that PM exercise will be more beneficial than AM exercise in improving insulin sensitivity. This study could identify if there is a better time of day to perform resistance exercise to decrease risk of developing Type 2 Diabetes Mellitus.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 50 Years 至 74 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Men and women, all ethnicities, aged 50-74 years
- •BMI ≥25 kg/m² and <45 kg/m²
- •Weight stable (less than 5% change in the past 6 months)
- •Generally healthy individuals
- •Not meeting recommended activity guidelines for aerobic or resistance exercise
排除标准
- •Uncontrolled cardiovascular, metabolic, renal, or pulmonary disease
- •Cancer treatment in the past 5 years
- •Untreated thyroid disease or other medical conditions affecting weight or energy metabolism
- •Current use of weight loss medication or other medications likely to impact energy balance
- •Bariatric surgery or extensive bowel resection in the past 2 years
- •Current or recent history (past 2 years) of eating disorder
- •Diagnosis of insomnia, sleep apnea, or other sleep and circadian disorders
- •Non-English speaking
- •HbA1c >6.5%
结局指标
主要结局
Insulin sensitivity
时间窗: 1 day
Insulin sensitivity will be calculated using the Matsuda Insulin Sensitivity Index
次要结局
- Sleep Duration(1 day)