ISRCTN15320623进行中（未招募）Unknown
Bronchiectasis Research Into Leukocyte biology and Lung Infections to Accelerate New Therapies (BRILLIANT)
niversity of Dundee0 个研究点目标入组 80 人开始时间: 2023年4月27日最近更新:
适应症
试验速览
- 阶段
- Unknown
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 80
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 性别
- All
入选标准
- •Bronchiectasis cohort:
- •1. Age >18 years
- •2. Bronchiectasis diagnosed by CT scan
- •3. Symptoms consistent with bronchiectasis: cough, sputum and/or frequent respiratory tract infections
- •4. Clinically stable defined by the absence of antibiotic therapy in the previous 4 weeks
- •Healthy control cohort:
- •1. Age >18 years
排除标准
- •Bronchiectasis cohort:
- •1. A primary diagnosis of asthma or COPD (secondary diagnoses and individuals with historical misdiagnosis will be permitted)
- •2. Immunodeficiency requiring immunoglobulin replacement therapy
- •3. Active allergic bronchopulmonary aspergillosis (defined by receipt of oral corticosteroids or anti-fungal therapy)
- •4. Active tuberculosis
- •5. Traction bronchiectasis due to interstitial lung disease
- •6. Active SARS-CoV-2 infection or contact with a confirmed case in the previous 14 days
- •7. Active malignancy excluding non-melanoma skin cancer
- •8. Antibiotic treatment for an acute respiratory tract infection or exacerbation in the previous 4 weeks
- •9. Treatment with anticoagulants
- •10. Any contraindication to study procedures including bronchoscopy
- •11. Current smoking or smoking in the preceding 3 months
- •Healthy control cohort:
- •1. Any respiratory diagnosis (asthma, COPD, bronchiectasis, pulmonary fibrosis or any other chronic respiratory condition requiring regular treatment)
- •2. Inflammatory conditions including rheumatoid arthritis, inflammatory bowel disease, and any other connective tissue disease
- •3. Active SARS-CoV-2 infection or contact with a confirmed case in the previous 14 days
- •4. Active malignancy excluding non-melanoma skin cancer
- •5. Antibiotic treatment for an acute respiratory tract infection in the previous 4 weeks
- •6. Any contraindication to study procedures including bronchoscopy
- •7. Current smoking or smoking in the preceding 3 months
- •8. Upper respiratory tract infection in the previous 4 weeks or current sinusitis
- •9. Treatment with anticoagulants
研究者
相似试验
已完成
不适用
Immunological Characterization of Bronchoalveolar Cells in NormalsLung DiseaseNCT00843414Ohio State University1,232
已完成
不适用
Investigation of lymphoid cells in bronchoalveolar lavage fluid of interstitial pneumoniaInterstitial pneumoniaJPRN-UMIN000024885Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine100
Unknown
不适用
Bacteriology and Inflammation in BronchiectasisBronchiectasisNCT01761214Guangzhou Institute of Respiratory Disease80
招募中
不适用
The BRIDGE Study - Bronchiectasis Research Involving Databases, Genomics and EndotypingBronchiectasis AdultNCT03791086University of Dundee1,000
已完成
不适用
Bronchoalveolar Immune Response DeterminationExtrinsic Allergic AlveolitisNCT01237145Bossink, A.W.J.10