oninvasive ventilation-neurally adjusted ventilatory assist (NIV-NAVA) compared to noninvasive ventilation-pressure support (NIV-PS) in post-extubated subjects on synchrony and work of breathing

Department of Intensive Care, Pamela Youde Nethersole Eastern Hospital0 个研究点目标入组 17 人开始时间: 2013年8月26日最近更新: 2020年1月13日

适应症

试验速览

暂无简介。

•1.Are currently or previously on mechanical ventilation for acute respiratory failure
•2.Are considered fit for extubation (defined as hemodynamic stability without the need for vasopressor support and a heart rate less than 110 beats per minute (bpm), respiratory rate less than 30 per minutes, and a Glasgow coma scale of E4VtM6), or has been extubated already
•3.Are indicated for NIV with >=1 of the risk factors for reintubation, including: chronic heart failure, COPD initially intubated because of an episode of acute hypercapnic respiratory failure, age >65, more than one consecutive failure of weaning trial before extubation, PaCO2 >45 mmHg (6 kPa) after extubation, weak cough
•4.Expected to require NIV for >=2 days
•5.Able to give consent to the study by him/herself.

•patients less than 18 years of age, pregnancy, with contraindications for insertion of nasogastric tube, or with contraindications for NIV (esophageal varices or obstruction, bleeding of the upper gastrointestinal tract, recent gastroesophageal surgery, hemodynamic instability or severe arrhythmia, facial surgery or trauma or deformity, severe upper airway obstruction, inability to cooperate or protect the airways, inability to cough or clear respiratory secretions, absence of a gag reflex and severe gastric distention), or contraindications to NAVA mode (known or suspected phrenic nerve dysfunction, and impaired respiratory drive).

发起方

Department of Intensive Care, Pamela Youde Nethersole Eastern Hospital