The effects of consumption of vitamin E or lipoic acid on serum oxyphytosterol concentrations in subjects with impaired glucose tolerance or type II diabetes - Antioxidants and oxyphytosterol concentrations

Medisch Universitair Ziekenhuis Maastricht0 个研究点目标入组 20 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•Aged between 18 and 75 years
•Body Mass Index (BMI) between 20-35 kg/m2
•Mean serum total cholesterol <8.0 mmol/L
•Mean serum triacylglycerol <3.0 mmol/L
•Diagnosed with diabetes mellitus type 2 on a clinical basis or impaired glucose tolerance (defined as blood glucose >7.8 mmol/l and <11.0 mmol/L, two hours after ingesting 75 gram glucose in 150 ml water)

•Unstable body weight (weight gain or loss > 3 kg in the past two months)
•Active cardiovascular diseases like congestive heart failure or recent (<6 months) event (acute myocardial infarction, cerebral vascular incident)
•Severe medical conditions that might interfere with the study such as epilepsy, asthma, chronic obstructive pulmonary disease, inflammatory bowel disease and rheumatoid arthritis
•Use of medication such as corticosteroids, diuretics or lipid lowering therapy
•Use of insulin therapy
•Abuse of drugs or alcohol (>21 units per week)
•Not willing to stop the consumption of vitamin supplements, containing lipoic acid and/or vitamin E, 1 month before the start of the study (wash-in period)
•Use of an investigational product within another biomedical study within the previous month
•Pregnant or breast-feeding women
•Current smoker

发起方

Medisch Universitair Ziekenhuis Maastricht