Nationwide Research on the Rewilding of Kindergarten Yards - Vahvistu
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 320
- 试验地点
- 3
- 主要终点
- Skin Gammaproteobacteria
研究概览
简要总结
Biodiversity is essential for nature and human well-being. Land use has reduced biodiversity in cities that is associated with altered commensal microbiota and a rising burden of immunological disorders among urban children.
The investigators will estimate how rewilding of kindergarten yards affects commensal microbiome, prevalence of allergies, asthma, atopic dermatitis and infections, cortisol levels, cognitive skills and plasma cytokine levels of children.
Our specific aims are:
To assess if rewilding diversifies health-associated skin, saliva and gut microbiota and reduces infectious diseases and atopic or allergic symptoms.
Assess whether the rewilding has positive effects on cognitive skills. Assess whether the rewilding changes cortisol and plasma cytokine levels. The investigators will recruit altogether 320 (160 per treatment) study subjects aged between 1-5 to questionnaire study (Task 2), from which 120 study subjects will be analyzed more detailed using microbiological and blood samples (Task 1).
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 1 Year 至 5 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Attendance in kindergarten
排除标准
- •Use of antibiotics in the year before sampling
结局指标
主要结局
Skin Gammaproteobacteria
时间窗: Baseline, 3 month, 1 year, 2 year, 3 year
Difference on skin gammaproteobacterial diversity between rewilding and control group
次要结局
- Difference in taxonomies of skin, saliva and stool microbiota(Baseline, 3 month, 1 year, 2 year, 3 year)
- White blood cell distribution(Baseline, 3 month, 1 year, 2 year, 3 year)
- Cortisol levels(Baseline, 3 month, 1 year, 2 year, 3 year)
- Microbial observed species richness(Baseline, 3 month, 1 year, 2 year, 3 year)
- Infectious diseases(Baseline, 3 month, 1 year, 2 year, 3 year)
- Asthma symptoms(Baseline, 3 month, 1 year, 2 year, 3 year)
- Allergy(Baseline, 3 month, 1 year, 2 year, 3 year)
- Patient-oriented Eczema Measure(Baseline, 3 month, 1 year, 2 year, 3 year)
- White blood cell transcriptomics(Baseline, 3 month, 1 year, 2 year, 3 year)
- Skin cytokines(Baseline, 3 month, 1 year, 2 year, 3 year)
- Difference in diversity of skin, saliva and stool microbiota(Baseline, 3 month, 1 year, 2 year, 3 year)
- Atopic dermatitis(Baseline, 3 month, 1 year, 2 year, 3 year)
- Plasma cytokines(Baseline, 3 month, 1 year, 2 year, 3 year)
- Wechsler Preschool and Primary Scale of Intelligence(Baseline, 3 month, 1 year, 2 year, 3 year)