Association Between Urine Concentration Ability and the Progression of Chronic Kidney Disease
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- eGFR slope
研究概览
简要总结
The study hypothesis is that urine concentrating ability can predict the rate of kidney function decline.
Patients with kidney disease at the investigatorsclinic will be asked to give first morning urine sample and osmolarity will be measured. The investigators will follow up kidney function decline and check if there is association with urine osmolarity.
详细描述
Design:
Prospective observational study
Setting:
Predialysis clinic.
Participants:
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with CKD and estimated GFR of less then 50 mL per minute estimated by the short MDRD equation base on two creatinine values taken at least two weeks apart and are not getting steroids or immunosuppressive medication as treatment for their primary kidney disease.
排除标准
- •Life expectancy of less then 6 month.
- •Expected to start renal replacement therapy within 3 month.
- •Acute or acute on chronic renal failure with reversible component.
- •Treatment with AVP inhibitors.
- •Chronic hyponatremia (Na+<135 in two measurement two weeks apart).
- •Primary polydipsia.
- •Inability to give informed consent.
- •Clinical hypovolemia.
结局指标
主要结局
eGFR slope
时间窗: 12 month
Creatinnie value will be measured at least every three month and eGFR will be calculated by MDRD equation. A regression line will be plotted against time and the eGFR slope will be calculated.
次要结局
未报告次要终点
研究者
Benaya Rozen-Zvi
attending nephrologist pre dialysis clinic Dan petach-tiqua county
Meir Medical Center