EUCTR2013-001659-10-BE进行中（未招募）不适用
Acute effects of Sildenafil on the hemodynamics, Right Ventricle performance and cyclic GMP concentration in Heart failure patients with preserved left ventricular ejection fraction and patients after heart transplantation (SIRVEH study) - SIRVEH study
ZLeuven0 个研究点开始时间: 2013年5月21日最近更新:
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •-Have LVEF > 45%
- •-During last 12 months
- •oWere hospitalized for heart decompensation and/or needed IV diuretics use
- •oWere catheterized for dyspnea and presented with PCWP > 15 mmHg and/or LVEDP > 18 mmHg
- •oAre on the chronic diuretics treatment and on the echocardiography have:
- •?E/E’ > 15
- •?8 < E/E’ < 15 and
- •E/A < 0.5 and DT> 280 ms OR
- •Ard-Ad > 30 msOR
- •LAVI > 40 ml/m²OR
- •LVMI > 122 g/m² (F) or > 149 g/m² (M) OR
- •NT-ProBNP> 400 pg/ml
- •For heart transplant patients
- •HTX patients with dyspnea and/or chronic diuretics treatment who
- •-Have LVEF > 45%
- •-During last 12 months presented with PCWP > 15 mmHg and/or LVEDP > 18 mmHg on the right heart catheterization (RHC)
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range 40
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range 20
排除标准
- •-Patients under 18 years of age
- •-Pregnancy
- •-Patients with severe valvular insufficiencies en stenosis
- •-Patients with the history of left ventricular dysfunction with LVEF< 45%
研究者
相似试验
已完成
不适用
The haemodynamic effect of sildenafil in mechanically ventilated patients with secondary pulmonary hypertension and ensuing right ventricular failure necessitating the administration of dobutamineSecondary pulmonary hypertension, right ventricular failureCirculatory SystemPulmonary hypertensionISRCTN35752874General State Hospital of Athens (Greece)12
进行中（未招募）
不适用
Hemodynamic effects of a single dose of sildenafil in symptomatic patients on bosentan treatment for pulmonary arterial hypertension A multicenter, open-label, non-comparative, prospective, phase II study - COMPASS 1Patients suffering from pulmonary arterial hypertension PAHMedDRA version: 6.1Level: PTClassification code 10037400EUCTR2005-005066-37-ITActelion Pharmaceuticals Ltd44
已完成
2 期
Effect of Sildenafil on Coronary Slow Flow PhenomenoCoronary Slow Flow Phenomenon.Atherosclerotic heart disease of native coronary artery with other forms of angina pectorisI25.118IRCT20220223054103N1Yazd University of Medical Sciences20
进行中（未招募）
不适用
ot applicableEUCTR2011-005333-39-GRational and Kapodistrial University of Athens31
已完成
2 期
Effects of Sildenafil on pulmonary artery pressure in patients with heart failure with preserved ejection fraction and pulmonary hypertensiodisturbed relaxation of the heartheart failure with preserved ejection fraction10019280NL-OMON38270niversitair Medisch Centrum Groningen52