NL-OMON47827招募中3 期
Multicentre Randomised trial of Acute Stroke treatment in the Ambulance with a nitroglycerin Patch - MR ASAP
niversitair Medisch Centrum Utrecht0 个研究点目标入组 1,400 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 发起方
- 入组人数
- 1,400
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 64（—）
入选标准
- •1. Age 18 years or older;
- •2. Probable diagnosis of acute stroke, as made by the paramedic in the prehospital setting;
- •3. Score of 2 or 3 on the Face Arm Speech Test (FAST);
- •4. Systolic blood pressure >= 140 mm Hg;
- •5. Possibility to start the trial treatment within 3 hours of symptom onset;
- •6. Intention to transport the patient to one of the participating hospitals;
- •7. Written informed consent (deferred).
排除标准
- •1. Considerable pre-stroke dependency in activities of daily living, defined as staying in a chronic nursing home or rehabilitation centre;
- •2. Known pregnancy or lactation;
- •3. Indication for acute treatment with nitroglycerin or known use of nitroglycerin in the previous 12 hours;
- •4. Indication for acute reduction of blood pressure;
- •5. Known hypersensitivity to GTN, nitrates in general, or the adhesives used in the patch
- •6. Glasgow Coma Scale < 8;
- •7. Known with any of the following heart disorders: myocardial insufficiency due to obstruction; aortic or mitral valve stenosis; constrictive pericarditis; hypertrophic obstructive cardiomyopathy; cardiac tamponade;
- •8. Known marked anaemia, defined as haemoglobin < 5 mmol/L;
- •9. Known closed angle glaucoma;
- •10. Known concomitant use of phosphodiesterase type-5 inhibitors, (e.g. sildenafil, tadalafil, vardenafil)
研究者
相似试验
进行中（未招募）
1 期
Study on the treatment with a nitroglycerin patch in the ambulance for patients with a strokeMedDRA version: 20.0Level: LLTClassification code 10042244Term: StrokeSystem Organ Class: 100000004852StrokeEUCTR2016-005086-31-NLniversity Medical Center Utrecht (UMCU)1,400
已完成
不适用
Treatment of acute exacerbations of asthma in children with a doubling of the usual inhaled corticosteroid (ICS) dose.AsthmaRespiratory - AsthmaACTRN12605000631606Asthma Foundation Queensland250
进行中（未招募）
1 期
A study comparing the effect of chemotherapy with the effect of chemotherapy plus local removal of metastases for patients with cancer of the large bowel which has spread to multiple organs.multi-organ metastatic colorectal cancerMedDRA version: 21.0Level: LLTClassification code 10052362Term: Metastatic colorectal cancerSystem Organ Class: 100000004864EUCTR2011-005003-32-NLVU University Medical Center, Department of Medical Oncology478
招募中
不适用
A randomized multicenter clinical trial for patients with multi-organ colorectal cancer metastases comparing the combination of chemotherapy and maximal tumor debulking versus chemotherapy alone.NL-OMON54652Radboud Universitair Medisch Centrum408
进行中（未招募）
不适用
A randomised multicenter clinical trial for patients with multi-organ, colorectal cancer metastases comparing the combination of chemotherapy and removing as many visible tumors as possible by surgery or other means versus chemotherapy aloneMulti-organ, colorectal cancer metastasesCancerISRCTN15067672Radboud University Medical Centre Nijmegen (Netherlands)478