Consistency of Fluid Tolerance Evaluation Methods and Their Correlation With Clinical Outcomes in Shock Patients:A Prospective, Observational Study
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- Hands-free Carotid Artery and Vein Doppler Parameters
研究概览
简要总结
This study aims to explore the feasibility and scientific validity of carotid-jugular Doppler in evaluating volume tolerance in shock patients (with the VExUS score as an important reference standard), and to conduct an in-depth analysis of the correlation between its monitoring indicators and patient prognosis.The primary endpoint is comparison of the agreement between hands-free carotid-jugular Doppler and the VExUS score in evaluating volume tolerance.The secondary endpoint is correlation between volume tolerance assessed by hands-free carotid-jugular Doppler and the clinical outcomes of shock patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Shock patients admitted to the ICU are defined as those with persistent hypotension (systolic blood pressure < 90 mmHg or a decrease of ≥ 40 mmHg from the baseline blood pressure) accompanied by signs of tissue hypoperfusion.
- •Age ≥ 18 years old.
- •The patient or their legal representatives signed the informed consent form.
排除标准
- •Patients with severe pulmonary circulatory disorders such as severe pulmonary hypertension and acute pulmonary embolism.
- •Patients with right ventricular myocardial infarction or severe tricuspid regurgitation.
- •Patients with severe neck trauma or deformity that affects Doppler examination of cervical arteries and veins, or those with anatomical contraindications preventing evaluation of at least one cervical artery or vein.
- •Pregnant or lactating women.
- •Patients with diseases that may interfere with abdominal ultrasound examination.
结局指标
主要结局
Hands-free Carotid Artery and Vein Doppler Parameters
时间窗: Time of shock in ICU within 3 days
Elevate the patient's upper body to 45°, keep the legs flat, place the long axis of the probe perpendicular to the carotid vessels (with the probe height not exceeding the upper edge of the thyroid cartilage), locate the optimal signals of the common carotid artery and internal jugular vein waveforms, and then fix the probe.
次要结局
- PiCCO(Time of shock in ICU within 3 days)
- Venous Excess Ultrasound Score(Time of shock in ICU within 3 days)
- Bioelectrical Impedance Analysis(Time of shock in ICU within 3 days)
- Duration of shock(Time of shock in ICU within 28 days)
- Duration of Mechanical Ventilation(up to 24 weeks)
- Total Length of Hospital Stay(up to 24 weeks)
- Length of ICU stay(up to 24 weeks)
- mortality of 28 days(Incidence of death during 28 days)
- In-hospital Mortality(up to 24 weeks)
- Vasoactive Agent Dosage(up to 24 weeks)
- Time without vasoactive agents within 28 days(Time without vasoactive agents within 28 days)
研究者
Ling Liu
Professor
Southeast University, China