Hyperbaric Oxygen Therapy and Insulin Resistance (HOTAIR2) - Effect of One HBO Session.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 9
- 试验地点
- 2
- 主要终点
- Insulin sensitivity
研究概览
简要总结
Obesity is an epidemic in Western society and is the biggest risk factor for insulin resistance and type 2 diabetes. The investigators have recently shown that exposure to hyperbaric oxygen (HBO) leads to an increase insulin sensitivity in males ubjects and that this improvement can be measured in all men, not just those with diabetes. The aim of this study is to investigate the time course of this effect and explore the mechanisms involved. The investigators suspect that insulin sensitivity as measured by hyperinsulinaemic-euglycaemic clamp will be increased within the time-frame of one 2-hour hyperbaric oxygen exposure, and that the improvement will be measurable in females as well as males.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Overweight to obese (BMI 25-35 kg/m2)
- •Age >18 years (no specific upper age limit)
- •Fit to enter hyperbaric chamber as assessed by hyperbaric physician.
排除标准
- •Personal history of Diabetes
- •Personal history of major psychiatric disorders
- •UIse of prescribed or non-prescribed medications which may affect glucose homeostasis (e.g. steroids),
- •Uncontrolled asthma,
- •Current fever or upper respiratory infections
- •Individuals who regularly perform high intensity exercise (>2 week),
- •Pregnancy, lactation and women who are planning to become pregnant
- •Current intake of >140g alcohol/week,
- •Current smokers of cigarettes/cigars/marijuana,
- •Current inatke of any illicit substance,
- •Claustrophobia
- •has donated blood within past 3 months.
结局指标
主要结局
Insulin sensitivity
时间窗: 2 hours
次要结局
- Hypoxia and inflammatory markers(2 hours)
研究者
A/Prof Leonie Heilbronn
A/Prof
University of Adelaide