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临床试验/NCT05587400
NCT05587400招募中不适用

The Consistency of Cardiac Output Measured by Electrical Cardiometry and Pulmonary Artery Catheter in Cardiac Surgery Patients With Pulmonary Arterial Hypertension or Right Heart Dysfunction

Shanghai Zhongshan Hospital1 个研究点 分布在 1 个国家目标入组 199 人开始时间: 2022年7月27日最近更新:
适应症
干预措施
相关药物

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
199
试验地点
1
主要终点
cardiac output by pulmonary artery catheter

研究概览

简要总结

Currently, the gold standard method to estimate CO in patients with PAH or RV dysfunction is pulmonary artery catheter (PAC), however, the invasiveness and complexity of PAC has limited its usefulness in many clinical scenarios. By measuring the thoracic electrical bioimpedance, electrical cardiometry (EC) technique has been reported to noninvasively estimate cardiac output (CO) and other parameters related to cardiac contractility and fluid status in various cardiovascular disorders. However, in patients with pulmonary arterial hypertension (PAH) and/or right ventricular (RV) dysfunction, few study has been reported. The aim of this study is to evaluate the agreement between CO measured by PAC as the referenced method and CO measured by EC technique in patients with PAH and/or RV dysfunction.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Diagnostic
盲法
None

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • adult cardiac surgery patients
  • pulmonary artery hypertension and/or right heart dysfunction
  • mechanical ventilation

排除标准

  • life threatening arrhythmia
  • severe valve regurgitation
  • left ventricular ejection fraction less than 30%
  • patients with mechanical circulatory support

研究组 & 干预措施

patients with pulmonary artery hypertension and/or right ventricular dysfunction

Experimental

干预措施: passive leg raising (Behavioral)

patients with pulmonary artery hypertension and/or right ventricular dysfunction

Experimental

干预措施: dobutamine test (Drug)

patients with pulmonary artery hypertension and/or right ventricular dysfunction

Experimental

干预措施: inhaled nitric oxide (Drug)

结局指标

主要结局

cardiac output by pulmonary artery catheter

时间窗: 30 minutes after nitric oxide inhalation

measuring cardiac output using pulmonary artery catheter

cardiac output by electrical cardiometry

时间窗: 30 minutes after nitric oxide inhalation

measuring cardiac output using electrical cardiometry

次要结局

未报告次要终点

研究者

发起方
Shanghai Zhongshan Hospital
申办方类型
Other
责任方
Sponsor

研究点 (1)

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