Imaging the Motor System in Parkinson's Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Functional MRI activity during a motor task
研究概览
简要总结
The study uses magnetic resonance imaging (MRI) to better understand changes in the brain underlying motor symptoms affecting upper and lower limbs in Parkinson's disease.
详细描述
There is a tremendous need to improve the understanding of the pathophysiology underlying motor symptoms in Parkinson's disease in order to optimize existing treatment options/develop new therapies. This study seeks to further the understanding of impaired movement in Parkinson's disease by examining brain changes and how these relate to changes in motor behavior.
The study uses magnetic resonance imaging (MRI), a noninvasive imaging technique that does not include X-rays. MRI will assess brain activity in response to simple and coordinated movements of the upper and lower limbs that participants have to perform inside the MRI scanner. Motor and cognitive function outside the scanner using various clinical and behavioral tests will also be assessed. The study includes 1 visit to the University of Delaware.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 45 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •A clinical diagnosis of Parkinson's disease
- •No neurological disorders if interested in participating as a control participant
- •Must be capable of providing informed consent
- •Must be eligible to receive a brain MRI
排除标准
- •A secondary movement disorder diagnosis in addition to Parkinson's disease
- •Medical conditions that may make one ineligible for receiving a brain MRI
- •Inability to provide informed consent
- •Control/healthy group: neurological disorders
- •Control/healthy group: cannot walk without an assistive device/mobility problems
研究组 & 干预措施
Parkinson's disease
Individuals with a clinical diagnosis of Parkinson's disease.
Healthy
Healthy individuals with no known neurological disorders.
结局指标
主要结局
Functional MRI activity during a motor task
时间窗: Baseline
Functional MRI activity during isolated/coordinated movements of the upper and lower limbs
次要结局
- Five Times Sit to Stand(Baseline)
- The Modified Clinical Test of Sensory Interaction and Balance (mCTSIB)(Baseline)
- Purdue Pegboard Test(Baseline)
- Parkinson's Disease Questionnaire (PDQ-39)(Baseline)
- Kinesia One(Baseline)
- Movement Disorder Society Unified Parkinson's Disease Rating Scale(Baseline)
- Schwab and England Activities of Daily Living Scale(Baseline)
- Timed Up and Go(Baseline)
- 360-Degree Turn Test(Baseline)
- 2-Minute Walking Test(Baseline.)
- Brief Test of Attention(Baseline)
- University of Pennsylvania Smell Identification Test(Baseline)
- Grooved Pegboard(Baseline)
- Montreal Cognitive Assessment Test(Baseline)
- Beck Depression Inventory II(Baseline)
- Rapid Eye Movement Behavior Disorder Questionnaire(Baseline)
- Epworth Sleepiness Scale(Baseline)
研究者
Roxana Burciu
Assistant Professor
University of Delaware