evaluation of resveratrol effect on the expression of the apoptosis-associated genes in granulosa cells of PCOS patients applicant to ART (triple-blinded randomized controlled trial)

Tehran University of Medical Sciences0 个研究点目标入组 40 人开始时间: 待定最近更新: 2024年1月22日

适应症

试验速览

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•patients must be infertile due to PCOS and aged between 18 and 40.
•PCOS is diagnosed based on Rotterdam criteria and having 2 of 3 criteria is enough for diagnosis: amenorrhea or oligomenorrhea, clinical or biochemical hyperandrogenism manifestations, observation of cysts in ovary sonography (at least 12 follicles with diameter of 2 - 9 mm or an increase in ovary volume more than 10cm in tans-vaginal ultrasound radiography).

•adrenal hyperplasia
•androgen secreting tumors
•hyperprolactinemia
•thyroid malfunction
•diabetes/glucose intolerance
•male infertility factors
•taking anti-oxidant supplements less than 6 months prior to entering the study.
•taking ovulation stimulating drugs less than 6 months prior to entering the study.
•taking drugs with effect on hormone profile less than 6 months prior to entering the study.

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