A Comparison of Propofol Based Total Intravenous Anesthesia and Desflurane Based Balanced Anesthesia on Hepatic Protection During Living-donor Liver Transplantation
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 136
- 试验地点
- 1
- 主要终点
- hepatic function
研究概览
简要总结
Renal ischemia/reperfusion (I/R)-induced injury is known to be associated with immediate and long-term hepatic dysfunction after liver transplantation. Protecting the liver against I/R injury and maintaining hepatic function during transplant surgery is therefore very important in order to improve post-operative outcome. This purpose of this study is to investigate whether propofol anesthesia done in both liver donors and recipients during living-donor liver transplantation is effective in reducing liver I/R injury via its antioxidant and antiinflammatory properties and improve post-transplant outcome compared to desflurane anesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •(1) Adult liver donors and recipients scheduled for liver transplantation
排除标准
- •Patient refusal
- •Hypersensitivity to propofol, soybeans or peanuts
- •History of vitamin C or E intake within 5 days before surgery
- •History of acute myocardial infarct within 6 months before surgery
- •Congestive heart failure (NYHA III-IV)
- •Autoimmune disease patients
- •BMI over 30 kg/m2
- •Left ventricular ejection fraction less than 35% upon preoperative echocardiography
研究组 & 干预措施
Desflurane balanced anesthesia group
干预措施: Desflurane balanced anesthesia (Drug)
Propofol total intravenous anesthesia group
干预措施: Propofol total intravenous anesthesia (Drug)
结局指标
主要结局
hepatic function
时间窗: from 48hr before anesthesia, 1 hour after reperfusion, 1 hour after end of operation, every 24 hours daily up to 7 days postoperatively
The difference in hepatic function of recipients between groups after liver transplantation (PT, aPTT, albumin, bilirubin, platelet count, AST, ALT, lactate, triglyceride, ammonia)
次要结局
未报告次要终点